Nibbling away at actin organization

Keep nibbling at the edges.

Alifelong passion for natural history and an aptitude for chemistry had led me to study for a B.Sc. in biochemistry at University College London (UCL) from 1963 to 1966. It was during this period that the allosteric theory of enzyme regulation was put forward by JacquesMonod, Jean-Pierre Changeux, and Francois Jacob at the Institute Pasteur. This explained how the end products of a biosynthetic...

Cohsasa--nibbling at the health care elephant.

Medicare reform: nibbling at catastrophic costs.

Multicolour Multilevel STED nanoscopy of Actin/Spectrin Organization at Synapses

Superresolution fluorescence microscopy of multiple fluorophores still requires development. Here we present simultaneous three-colour stimulated emission depletion (STED) nanoscopy relying on a single STED beam at 620 nm. Toggling the STED beam between two or more power levels ("multilevelSTED") optimizes resolution and contrast in all colour channels, which are intrinsically co-aligned and we...

Squirreling away at Parkinson's.

A compound that triggers hibernation in ground squirrels can also protect brain cells from the lack of oxygen following a stroke.